Presentatör: Romana Stehlik, läkare, PhD, Smärtcentrum

Uppsala Akademiska sjukhuset/Uppsala Universitet

Background: The chronic pain (CP) and chronic multi-site pain (CMP) condition is a highly prevalent health problem. Several studies have reported a high (31–64%) prevalence of co-morbid restless legs syndrome (RLS) and dyssomnia (60-90%) in patients with fibromyalgia, one specifically defined form of chronic widespread pain. Dyssomnia refers to the collection of sleep disorders that negatively impact the quantity and quality of sleep. This study aimed to investigate quality of life in subjects with pain, dyssomnia and Restless legs syndrome.

Method: The study included 4040 respondents to a postal questionnaire sent to 10,000 women in the age range of 18–64 years and randomly selected from the general population in Dalarna, Sweden. Complete questionnaire data on type (acute/chronic), degree (mild to severe) and spreading (0–5 body zones) of pain, as well as RLS symptoms (validated questionnaire), self-reported sleep quality and quality of life (SF-36) were obtained from 3060 subjects. Information on lifestyle, anthropometrics, co-morbidities and medication was collected.

Results: Subjects with pain, RLS and dyssomnia scored substantially lower on all SF-36 subscales compared to subjects with no pain; pain only; pain, RLS and pain and dyssomnia (Kruskal-Wallis p<0,0001). The quality of life decreases with increasing amount of pain localization and RLS diagnosis (Kruskal-Wallis p<0,001). Subjects with RLS, pain and dyssomnia exhibited lowest scores on all SF-36 mean scores and on the Physical Composite Score and Mental Composite Score controlling for anxiety and depression in a multiple regression analysis.

Conclusion: Subjects with pain, dyssomnia and RLS exhibits the lowest quality of life compared to subjects with pain only, pain and dyssomnia and pain and RLS. The quality of life deteriorates also with the degree of pain spreading in women recruited from the general population.